Dr. Unnati Mamtora
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Repeated IVF Failure Treatment Mumbai

Understanding Repeated IVF Failure

Repeated IVF failure (RIF) is defined as failure to achieve a clinical pregnancy after three or more high-quality embryo transfers. It is a distressing situation that affects approximately 10–15% of couples undergoing IVF, and it demands a thorough, systematic investigation to identify underlying causes.

Dr. Unnati Mamtora takes a methodical, compassionate approach to couples who have experienced repeated disappointment. Rather than repeating the same protocol, a comprehensive re-evaluation is performed to identify correctable factors — and a personalised treatment plan is designed accordingly.

Common Causes of Repeated IVF Failure

  • Chromosomal abnormalities in embryos (most common — detected with PGT-A)
  • Poor egg or embryo quality
  • Uterine structural issues (fibroids, polyps, adhesions, or uterine septum)
  • Implantation failure due to thin endometrium or poor receptivity
  • Thrombophilia or immune-mediated implantation failure
  • Sperm DNA fragmentation
  • Suboptimal ovarian stimulation protocol

Our Investigation & Treatment Approach

1
Detailed Cycle Review

Complete analysis of all previous IVF cycles — stimulation protocols, embryo grades, endometrial thickness, and transfer reports.

2
Genetic Testing (PGT-A)

Preimplantation Genetic Testing screens embryos for chromosomal abnormalities, ensuring only euploid embryos are transferred.

3
Uterine Assessment

Hysteroscopy to directly visualise the uterine cavity and identify or treat polyps, fibroids, adhesions, or septa.

4
Endometrial Receptivity

ERA (Endometrial Receptivity Analysis) testing to identify the personalised window of implantation unique to each patient.

5
Immune & Clotting Panel

Testing for antiphospholipid antibodies, natural killer cell activity, and thrombophilia — treatable causes of implantation failure.

6
Sperm DNA Fragmentation

Assessment of sperm DNA integrity, with advanced selection options — IMSI, PICSI, or MACS — to use the healthiest sperm.

Frequently Asked Questions

Most specialists define RIF as three or more failed transfers of good-quality embryos. However, if two high-quality blastocysts have failed to implant, an early investigation is often warranted — there is no benefit in waiting for a third failure.

Not at all. In most cases, a correctable cause is identified. With the right investigation and adjusted protocol, many couples with a history of repeated IVF failure go on to achieve a successful pregnancy.

The ERA (Endometrial Receptivity Array) is a genomic test that identifies the precise window in which the uterine lining is most receptive to embryo implantation. It is particularly recommended when good-quality embryos have repeatedly failed to implant.

Donor eggs may be recommended if poor egg quality is identified as the primary cause and cannot be improved with protocol changes. This decision is made only after thorough investigation and discussion of all available options.

Book a Consultation

Speak with Dr. Unnati about your fertility journey.

Book Appointment +91 9930040177

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